I have a tall, wide Pirelli MT43 4.00x18 tire on the back of mine (I believe the circumfrence is the same as a roadgoing 4.00x19 tire), and I have to keep the snail cams adjusted out a ways to keep the tire from rubbing my swingarm. When adjusted well, though, I get some fore-aft chain adjustment and a solid 6mm clearance for mud and terrestrial frogs to pass.
If you're handy you can clearance the swingarm to fit more meat, with some flat plate, a grinder, hammer and a welder.