A good friend with a 2012 C5 was running Castrol semi-synthetic for a long while in his bike with no issues.
He decided to "upgrade" his oil to full synthetic Amsoil and started missing shifts.
He went back to the Castrol and his shifts became normal again.
Who knows...magic?
After changing oil with a different slipperiness
(if there is a word like that, but you get my point ), the clutch/friction plates do not engage the way they used to, because the clutch cable was set to different characteristics of the oil. UCE engines are fed by the same oil that goes to transmission and clutch.
On changing characteristics of oil, the clutch cable needs adjustment. It may take a very small adjustment - sometimes as little as 1/2 to 1 turn of the clutch cable lock/adjustment nut that will fix the problem.
Full synthetic oil works very well, and so does semi-synthetic - as long as the bike clutch is set properly.
In some cases, synthetic oil leaks out more often than semi-synthetic oil, from very narrow gaps in gasket/covers. Such leaks are very minimal without any serious consequences, if they do occur at all.