I was looking at some U-tube vids of people doing this, building grids of cells. One benefit was that you would know you had decent quality cells. ( Samsungs were said to be good quality at reasonable price) Inexpensive sealed purchased packs might be filled with who knows what ("satisfacton cheerful batery"), and quality both in terms of capacity and longevity varies widely between reputable product and substitutes. I've experienced some pretty awful quality in aftermarket digital camera batteries.
Also having the ability to build gives one the ability to repair, which comes down to finding the weak cell(s) and replacing them.
From what I saw, building packs came down to the ability to source or make the connector buss elements from thin sheet, and the possession of a low powered spot welder. As I recall, some people were building these from microwave oven transformers with the secondary coil rewound to low voltage, high current. The fancy ones had a pulse timing setup.
I'm sure I'm simplifying, it might be nice to also have some built-in charge management, maybe even a way to switch the pack into different grid configurations for different voltage and charging options.
What are you thinking of using for a housing? A buddy of mine had a home built vac forming setup in his garage for a while, and fiberglass is nice for free form boxes.