Depends on certain factors.
AGE: As an 18 yr. old with high T, I rode my 72 350 Honda from Long Island , NY to Montreal for a night with a girl. Would not do that now. No longer have enough T and ass padding.
LOCATION: The RE 650 is my favorite bike for county roads, twisties, within the city, and generally between 40 and 60 MPH.
I love the bike, and could certainly have it as my only ride. But let's face it, there are other machines that could handle high speed interstates and and 12 hour days in the saddle a bit better, Granted those machines would lack the same grin factor as the RE in it's element.
PRICE POINT: What's in your wallet. RE 650 shines