A couple of years ago I used Slime when I got a air leak on my Zero's rear tubeless tire a few years ago. After I arrived home I noticed that the Slime was leaking out of the nail hole. So I plugged the tire. Bad decision. After about 5 miles the plug came out of the tread when the Slime acted like a lubricant and the tire went flat again. What I had to do was to thoroughly clean the hole with alcohol, roughen it up again and then install a new plug. That worked well until the tire wore out. Upon removing the tire, I there was not much of a mess and it was easy to clean the wheel rim with a wet rag. After that experience, I decided to no longer carry a bottle of Slime on my bikes and just stick to a compact plugger system.
About 20 years ago I got a flat tire from a nail in the tube-type tire of my BMW Funduro. I inserted Slime in the tube in the hope of being able to ride the bike the 10 miles home, but it just ran out of air after three miles. After stopping several times to refill the tire with air, I finally gave up and rode home on the flat tire. Kind of scary when cornering, but I managed to make it home and ended up installing a new tube. That was the permanent fix.