Air is already 78% nitrogen as it is.
There's 21% oxygen, and1% trace gases.
So, while there's a small benefit in less permeation of nitrogen out thru the rubber, which BTW is very minor, even with oxygen, it amounts to less than 2 psi per month. Often quite a bit less than that.
The issue with moisture is primarily involving tubeless tires and the corrosive effect of the moisture and oxygen on the rims. This isn't an issue at all with tube type tires such as we have.
To me, the very small advantages that can be had from this, are far more than offset by being able to stop at a gas station and set your tire pressures at the air pump, or do it at home, instead of going to a special shop and paying to have your tire pressures set.
The increased tire wear comes from lowered pressure. If you check and set your air pressures once a month or so, you won't have reduced pressures, and the tire wear situation becomes moot.
A simple foot pump or hand pump at home can accomplish this very easily and cheaply.