Ace, you’re certainly far, far more knowledgeable than I on such things, but speaking from personal experience, jetting might well need to be adjusted a bit when running 100% AvGas/100LL.
Since fuel might often stay in my bike's tank for 6 months or more, I now use 100LL and definitely had to richen the mixture a bit over “pump gas" to keep everything happy. A bit more than a 1/8 turn in on the idle, a notch on the needle and a wee bit more height on the float level. I believe this was due to differences in the specific gravities of the fuels.
That said, the bike runs wonderfully on AvGas and I’ve never had a fuel/ carb issue; even if the bike sits for months. Plus, the occasional whiff of it in the exhaust is magical.