I haven't used it on my bike but the company I retired from used it all over the place on the jet engines and gas turbines we built. (They are even better at loosening nuts than Royal Enfields, if you can believe that.)
One of the more common locations for lock wire was on the tubing nuts and fittings.
Most of the other nuts we used were self locking such as MS21043 which we used by the thousands.
There were a few applications where we needed lock wired bolts and nuts that were made out of exotic materials which were not commonly available.
For these, we built a special drilling machine which would clamp on the hexagon.
Hardened drill bushings were located in the clamping jaws. These bushings had the end that would be next to the bolt head or nut ground off flush with the clamping surface of the jaws.
This was needed because at the start of the drilling, the small drill bits were asked to make an interrupted cut where it was cutting only on one side.
With the bushing ends ground flush with the jaws surfaces, they would provide the support for the non-cutting side of the bit while this was happening.
The drill motors were special too.
With the small drill bits cutting some very hard to machine materials like Inconel718 and Rene'41 it was important to limit the speed and power being used to prevent burning up the small drill bits but also preventing the work hardening that can occur if the drill were to stop cutting even for an instant.
To do this special torque and speed sensors were employed.
My advice to anyone who is considering using lock wire is they need to look for bolts and nuts that have already been drilled. The big factories can afford the special equipment that's needed to produce these items.
If you intend to make some special jaws with holes to guide the drill bits plan on buying
lots of drills. You're going to need them.