Hi Joe,
I try to treat these bikes all individually. There are differences.
We just want to get what works on your bike.
Now, we've seen that with much larger jets, you get poor fuel mileage, but it runs.
Since then, you've leaned out considerably, and now it's not running so good.
That tells me you have to find a middle ground.
Yes, 2500' elevation should cause richer mixture, and expect to jet a little leaner.
However, there could be all kinds of things involved here, including your exhaust system and air filter system, and even individual characteristics of the engine internally.
So, I just do what works for the bike that I'm working on, and the others might only be a general guideline.
Also, be aware that when you get too lean, it can become very sensitive, and cough and sputter and act pretty bad. The fact that you can bottom-out the bleed screw is a clear indicator of needing the next pilot jet size.
If I was doing this, my next move would be a step richer in everything, and see how that does.